Doctors often prescribe statins to treat CVD. These drugs work by reducing the cholesterol production that can contribute to the disease.
Although statins reduce cholesterol production, they also lower CoQ10 levels. Reduced CoQ10 levels can lead to mitochondrial dysfunction, which can cause muscle pain , or myopathy. A randomized controlled trial investigated the effect of CoQ10 on statin-related muscle pain.
The study involved 60 participants who had previously reported muscle pain while taking statins. Over 3 months, each participant received daily doses of either mg of CoQ10 supplement or a placebo. The participants who took the CoQ10 supplements had significantly reduced statin-related muscle pain. Those who received the placebo reported no change in muscle pain.
However, the authors of a meta-analysis evaluated the efficacy of CoQ10 supplementation for treating statin-related muscle pain. The meta-analysis included six studies with a combined total of patients. The authors found no evidence that CoQ10 significantly improves statin-related muscle pain. Further large-scale RCTs are necessary to determine whether CoQ10 is a viable treatment for people experiencing statin-related muscle pain.
Chronic migraines may be due to inflammation of neurons and cells in a part of the brain called the trigeminovascular system. A clinical trial investigated whether coQ10 supplements could reduce inflammation in 45 women with episodic migraines.
The women took mg daily doses of either a CoQ10 supplement or a placebo. The women who took the CoQ10 supplements had fewer and less intense migraines when compared to the placebo group. Women who took the CoQ10 supplements also showed lower levels of certain inflammatory biomarkers. Inflammatory biomarkers are substances in the blood that indicate the presence of inflammation somewhere in the body. A meta-analysis reexamined five studies investigating the use of CoQ10 supplements for migraines.
The meta-analysis concluded that CoQ10 is more effective than a placebo at reducing the duration of migraines. However, CoQ10 did not appear to affect migraine severity or frequency. These diseases are associated with free radical damage.
A study investigated the effect of a Mediterranean diet combined with CoQ10 supplementation on metabolism in elderly adults. This combination led to an increase in antioxidant biomarkers in the urine. The authors concluded that taking CoQ10 and eating a diet low in saturated fat may help protect against diseases caused by free radical damage.
In another study , older adults received CoQ10 and selenium supplements for 48 months. The participants reported improvements in vitality, physical performance, and overall quality of life. CoQ10 supplements appear to be safe, and most people tolerate them even at high doses.
However, CoQ10 supplements can cause the following side effects:. People should consult a doctor before taking any new medications or dietary supplements, including CoQ CoQ10 is an antioxidant that exists in almost every cell of the human body. Although the body naturally produces CoQ10, some people may benefit from taking supplements. Overall, CoQ10 supplements appear relatively safe and cause few side effects. However, one study reported that CoQ10 was an important factor in the survival of older adults with chronic heart failure.
Other research showed that CoQ10 might help people recover from some types of heart surgery. According to both the American Academy of Neurology and the American Headache Society, CoQ10 may be effective in preventing migraines, although the research to support this is still limited. It is possible that CoQ10 has this effect because it keeps the mitochondria in the cells healthy.
Some research suggests that CoQ10 might help ease muscle weakness that is due to taking cholesterol-lowering medications, known as statins. However, the results of another trial showed that treatment with CoQ10 did not reduce muscle pain in people who were also using statins to control their cholesterol levels.
People can obtain CoQ10 by eating certain meats and grain proteins, but the quantity present in these foods is too small to increase CoQ10 levels in the body significantly. CoQ10 supplements are available to take either by intravenous IV injection or as capsules or tablets.
Studies have used daily doses of CoQ10 ranging from 50 milligrams mg to 1, mg in adults. A typical daily dose for someone who has a CoQ10 deficiency is — mg , while the observed safe level is 1, mg per day.
Studies have shown a significant reduction in plasma CoQ10 concentrations following treatment with statins. Additionally, CoQ10 may reduce the effectiveness of blood-thinning drugs, such as warfarin, and this may increase the risk of blood clots. CoQ10 may also interfere with insulin and some chemotherapy medications.
Coenzyme Q10 CoQ10 is a naturally occurring antioxidant that is present in almost every cell in the human body. Scientists have linked low levels of CoQ10 with various medical conditions, including heart disease and cancer. People usually tolerate CoQ10 supplementation well, and the supplements produce few, if any, side effects. However, there is limited research to support the health benefits that CoQ10 might offer.
People can buy CoQ10 supplements in drug stores or online. It is essential to speak with a healthcare professional before taking any new dietary supplements, including CoQ Statins are drugs that can reduce levels of cholesterol in the blood. Abnormal mitochondrial function has also been linked to insulin resistance CoQ10 has been shown to improve insulin sensitivity and regulate blood sugar levels Supplementing with CoQ10 might also help increase CoQ10 concentrations in the blood by up to three times in people with diabetes who typically show low levels of this compound 37 , Also, one study had people with type 2 diabetes supplement with CoQ10 for 12 weeks.
Doing so significantly reduced fasting blood sugar levels and hemoglobin A1C, which is the average of blood sugar levels over the past two to three months Lastly, CoQ10 might help prevent diabetes by stimulating the breakdown of fats and reducing the accumulation of fat cells that could lead to obesity or type 2 diabetes Summary: Supplementing with CoQ10 can help increase insulin sensitivity and improve blood sugar levels.
Oxidative stress is known to cause cell damage and affect their function If your body is unable to effectively fight oxidative damage, the structure of your cells can become damaged, possibly increasing the risk of cancer 41 , CoQ10 may protect cells from oxidative stress and promote cellular energy production, promoting their health and survival 42 , Low levels of CoQ10 have been associated with up to a Summary: CoQ10 plays a critical role in the protection of cell DNA and cell survival, both of which are strongly linked to cancer prevention and recurrence.
Mitochondrial function tends to decrease with age. Unfortunately, the brain is very susceptible to oxidative damage due to its high fatty acid content and its high demand for oxygen.
This oxidative damage enhances the production of harmful compounds that could affect memory, cognition and physical functions 48 , Summary: CoQ10 has been shown to protect brain cells from oxidative damage and reduce the action of harmful compounds that can lead to brain disease. Of all your organs, your lungs have the most contact with oxygen.
This makes them very susceptible to oxidative damage. Increased oxidative damage in the lungs and poor antioxidant protection, including low levels of CoQ10, can result in lung diseases like asthma and chronic obstructive pulmonary disease COPD Furthermore, it has been shown that people suffering from these conditions present lower levels of CoQ10 53 , A study demonstrated that supplementing with CoQ10 reduced inflammation in individuals who had asthma, as well as their need for steroid medications to treat it Another study showed improvements in exercise performance in those suffering from COPD.
This was observed through better tissue oxygenation and heart rate after supplementing with CoQ10 Summary: CoQ10 can reduce oxidative damage and inflammation that results in diseases of the lungs.
If you want to buy a CoQ10 supplement containing the ubiquinol form, then there is an excellent selection on Amazon. The standard dose of CoQ10 ranges from 90 mg to mg per day. Doses up to mg seem well tolerated, and several studies have used even higher doses without any serious side effects 59 , 60 , Because CoQ10 is a fat-soluble compound, its absorption is slow and limited.
However, taking CoQ10 supplements with food can help your body absorb it up to three times faster than taking it without food 2 , Additionally, some products offer a solubilized form of CoQ10, or a combination of CoQ10 and oils, to improve its absorption 63 , 64 , Your body does not store CoQ Therefore, its continued use is recommended to see its benefits 58 , Supplementing with CoQ10 appears to be well tolerated by humans and have low toxicity In fact, participants in some studies showed no major side effects taking daily doses of 1, mg for 16 months However, if side effects appear, it is recommended to divide the daily dose into two to three smaller doses.
Summary: Since CoQ10 is fat-soluble, it is recommended to take it with food or use products that combine it with oils to improve its absorption. Supplementing with CoQ10 appears to be well tolerated by individuals and has low toxicity. It appears that CoQ10 is similarly absorbed in capsule form or through foods Summary: CoQ10 is found in some foods, especially organ meats.
These properties make it helpful in the preservation of cells and the prevention and treatment of some chronic diseases. CoQ10 has been shown to help improve heart health and blood sugar regulation, assist in the prevention and treatment of cancer and reduce the frequency of migraines. It could also reduce the oxidative damage that leads to muscle fatigue, skin damage and brain and lung diseases. CoQ10 can be found as a supplement that seems to be well tolerated.
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